08 July 2019 10:00 - 11:00

Sessile multicellular microbial communities termed biofilms are formed by most, if not all microorganisms, which can persist in a multitude of environments. A major virulence factor in chronic infections is biofilm formation recalcitrant towards antimicrobials. Understanding the molecular basis of biofilms will aid the development of novel antimicrobial substances. This section will cover diverse research aspects of biofilm formation by Gram-negative and Gram-positive pathogens such as Burkholderia cenocepacia, Salmonella typhimurium, Escherichia coli, Vibrio cholerae and Staphylococcus aureus.  Lectures will describe the molecular basis of regulation of biofilm formation by ubiquitous cyclic dinucleotide second messenger signaling systems, molecular mechanisms of adhesion and novel aspects of functional benefits of multicellular biofilm behavior. Novel imaging techniques to trail dynamic processes in biofilms on the single cell level will be addressed. Such will this symposium touch upon the breadth and the depth of biofilm formation in bacterial pathogens.


Ute Römling, Karolinska Institutet, Sweden

Leo Eberl, University of Zürich, Switzerland

Joan Geoghegan, Trinity College Dublin, Ireland

Knut Drescher, Max Planck Institute for Terrestrial Microbiology, Germany


Regulation of biofilm formation in Salmonella typhimurium and Escherichia coli
Ute Römling - Sweden
08 July 2019 10:00 - 10:30

The BDSF quorum sensing signal controls polysaccharide production in Burkholderia cenocepacia via modulating the intracellular c-di-GMP level
Leo Eberl - Switzerland
08 July 2019 10:30 - 11:00