HEV - From virology to treatment

 Viral hepatitis

Channel 1
English
Interactive Session
27 August 2020 17:00 - 18:00

Hepatitis E virus (HEV) is one of the most common causes of acute hepatitis and jaundice in the world. HEV genotypes 1 and 2 are transmitted from humans to humans and cause primarily waterborne outbreaks in resource-limited settings while genotypes 3 and 4 have emerged as primarily porcine zoonosis. HEV genotype 3 (and, to a lesser extent, genotypes 4 as well as 7) can persist in immunocompromised patients and cause chronic hepatitis with potential rapid progression to cirrhosis. In addition, HEV can cause diverse neurological as well as other extrahepatic manifestations and trigger acute-on-chronic liver failure in patients with preexisting cirrhosis.

 

This symposium shall provide a state-of-the-art update on hepatitis E, including an overview on current hot topics in this area, the molecular virology and pathogenesis of hepatitis E as well as the prevention and treatment of HEV infection. The expert speakers shall

 

-          provide a primer on the epidemiology, clinical manifestations, diagnosis and management of acute and chronic hepatitis E,

-          highlight advances in research on the HEV life cycle and the identification of targets for antiviral intervention,

-          discuss the immune response to HEV as well as determinants of infection outcome and

-          provide an overview of current and emerging preventive as well as therapeutic strategies.


Presentations

Title Time

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Introduction
27 August 2020 17:00 - 17:03
A primer on hepatitis E: What's hot in 2020?
27 August 2020 17:03 - 17:13
Molecular virology of hepatitis E
27 August 2020 17:13 - 17:23
Pathogenesis of hepatitis E
27 August 2020 17:23 - 17:33
Prevention and treatment of HEV infection
27 August 2020 17:33 - 17:43
Roundtable discussion
27 August 2020 17:43 - 18:00