Pathogens & Diseases symposium: Pathogenesis of tuberculosis

08 July 2019 10:00 - 11:00

To be discussed, a diverse set of topics addressing that common theme: i) how definition of the structure, biogenesis, and genetics of the cell wall of Mtb helps define the role in pathogenesis of crucial cell wall entities such as, phthicerol dimycocerosate, trehalose dimycolates, sulfolipids, lipoarabinomannan, and even those subtle appendages on the cell wall core; ii) the cell surface protein, Erp, known to be required for mycobacterial growth in macrophages and virulence has long defied definition of mechanism of virulence; new functional, biochemical and structural data rectifies that deficiency; (iii) present-day highly pathogenic strains of Mtb have genetically evolved from a pool of ancestral, extant, non-pathogenic environmental mycobacteria, known as M. canettiiiv) The development of a new innovative human challenge model of TB holds promise for new perspectives on pathogenesis, vaccine and drug development.


Patrick Brennan, Colorado State University, United States (Chair)

Brian Robertson, Imperial College London, England, UK

Roland Brosch, Institut Pasteur, France

Lalita Ramakrishnan, Cambridge University, England, UK


Title Time Appointment Abstract
Molecular Effectors of TB Pathogenesis
08 July 2019 10:00 - 10:30
Development of a Human challenge model for Tuberculosis
08 July 2019 10:30 - 11:00